S-4

[CJ220]

Sarm any info on this new product?????

100mg per capsul...thought to have same effects as test propionate....but with no sides....anyone with experiences??????

[Mallet]

Is this suppose to be an OTC product or still an illegal product?

[stbizzle]

I was using 100mg a day is liquid. I don't know where your finding casuals but I'd be careful and make sure it's the real deal. There's only one place I know of right now where you can get legit stuff from. It could be comparable to TP as far as anabolic effects but dose nothing for libido. You will notice an increase in hunger and strength right off the bat within hours of taking it. Your muscle will be extremely hard and you will have more energy in the gym. I quit taking it because my diet was s hit and I was gaining more weight than I wanted to at the time. It's very good stuff.

All you need for your animal research is 1mg to 2mg per kilogram of bodyweight for daily.


SARMs were created to replace HRT and there are several forms of SARMS including S1, S2, S3 and S4. S4 displays high binding affinity on muscle tissue with very little to no binding affinity to other organs and tissues such the liver, heart or prostate as compare to synthetic testosterone PLUS is is MG per MG as anabolic as Test Propionate but WITHOUT the androgenic effects which means it will not be a mass gainer as regular Test due to the fact that it is lacking its androgenic side but still a great clean, non hormonal HRT replacement.


Here are other highlights:




* Users have reported fuller, harder muscles with increased definition
* Users have reported aggression and physical strength ( dose dependent )
* Users have reported increased libido, especially those who have depleted levels of Testosterone ( Perfect for PCT )
* It increases fat utilization leading to increased energy expenditure ( Increased energy! )
* It possesses the same fat burning effects of testosterone
* MG per MG as anabolic as Testosterone Propionate in skeletal muscle only.
* Low binding affinity to prostate , heart, liver and other organs
* Little to no androgenic side effects ( dose depending of course )
* Non hormonal so there is no hormonal disruption and NO estrogen conversion
* Increases appetite and sense of well being
* 91% Orally active in liquid form
* Fast acting, half life is of 4 hours




* Side effects may include:

Headaches, ocular migraine, increased appetite and increased sweating, hyperactivity rarely occurs but has been reported.

The headaches subside within 2 weeks of use in most cases and are sign your test subject is in need of more protein, adding more protein to you diet may help get rid of the headches. Ocular migraine manifests by seeing yellowish tints on lights ( auras) this is common effect of ocular migraines and is not treatable or harmful, give your subject test more protein because its body is craving for it while on Sarms

These side effects are not uncommon with Serms as well, Clomid causes blurry vision sometimes.



Pharmacodynamics of selective androgen receptor modulators.
Yin D, Gao W, Kearbey JD, Xu H, Chung K, He Y, Marhefka CA, Veverka KA, Miller DD, Dalton JT.

Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA.

The present study aimed to identify selective androgen receptor modulators (SARMs) with in vivo pharmacological activity. We examined the in vitro and in vivo pharmacological activity of four chiral, nonsteroidal SARMs synthesized in our laboratories. In the in vitro assays, these compounds demonstrated moderate to high androgen receptor (AR) binding affinity, with K(i) values ranging from 4 to 37 nM, and three of the compounds efficaciously stimulated AR-mediated reporter gene expression. The compounds were then administered subcutaneously to castrated rats to appraise their in vivo pharmacological activity. Androgenic activity was evaluated by the ability of these compounds to maintain the weights of prostate and seminal vesicle, whereas levator ani muscle weight was used as a measure of anabolic activity. The maximal response (E(max)) and dose for half-maximal effect (ED(50)) were determined for each compound and compared with that observed for testosterone propionate (TP). Compounds S-1 and S-4 demonstrated in vivo androgenic and anabolic activity, whereas compounds S-2 and S-3 did not. The activities of S-1 and S-4 were tissue-selective in that both compounds stimulated the anabolic organs more than the androgenic organs. These two compounds were less potent and efficacious than TP in androgenic activity, but their anabolic activity was similar to or greater than that of TP. Neither S-1 nor S-4 caused significant luteinizing hormone or follicle stimulating hormone suppression at doses near the ED(50) value. Thus, compounds S-1 and S-4 were identified as SARMs with potent and tissue-selective in vivo pharmacological activity, and represent the first members of a new class of SARMs with selective anabolic effects.

PMID: 12604714 [PubMed - indexed for MEDLINE]

what I noticed to be true are in bold

[stbizzle]

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